Agree on shot placement. I have only ever hunted with a 308. Last bull I took this past fall was at 182 yds through a keyhole opening in the aspens. He dropped where he stood. Last muley two weeks later was at 335 yds; put the round right behind the shoulder and took out both lungs. He went 45 yds into the brush and dropped. The buck in 2020 was at 225 yds in southwest Wyoming. Hit him low in the boiler room and took out the heart and one lung. He stood where I shot him for about 20 seconds and then just dropped. All three of these were with a 165 TBT. Devastating round that I can get 0.8 MOA accuracy with. Shot placement and high performing bullet works every time. With rangefinders and CDC systems on my VX6, compensating for bullet drop isn't an issue and my 308 is light and soft shooting. Can't beat that combination for high country Colorado hunting.
I would trust my 308 anywhere. But I do use my 300 out west due to the fact we have never shot under 300 and routinely shoot in the 5-600 range. With said same grain of rounds the 308 drops around 14in at 300yds and 60in at 500yds, where as the 300 drops 8 at 300yds and 38in at 500 yds. So quite the difference.