I'm a fan of the .25-06, but for elk? Even 120 gr bullet is pretty light to take down a big animal. Sure you can probably do it, but what if the damn thing runs off wounded? Is that ethical? I can drive my car with bare feet, but is it a good idea? I have a .30-06 and a 7mm Rem Mag. That .25-06 is probably only good out to 300 yards. The 7mag has a lot more punch and can reach out and touch some one! The .280 AI I'm sure is a good round, but what if you have to buy ammo from a retail store?? You are up sht creek without a paddle. I say, most of the time, It's not the arrow but the indian! You asked, my take. Watch the guy Desert Dog on Youtube. He's a fan of the .30-06 and 7mm-08. He has some really good advice and no axe to grind. He ain't taking graft from the ammo companies.