IMO it depends on type of game ... knowing your rifle....etc,... most of everything has been covered here.... I have no problem shooting over 400 at a pig/coues with a 25-06 or a 7mag with 110 grns...I have never used a range finder... and 99% of the time its a 1 shot 1 kill....Elk being the exception...coyotes are I shoot at them no matter what... Even a hail Mary shot will be attempted