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Not that particular bullet but, I've killed a couple deer with the 200 grain version and my brother killed a deer with the 220 grain version. Brother got a passthrough and good performance at 150 yards. My longest shot was 160 yards and closest was maybe 20 yards on mule deer. All one shot kills. Had good accuracy out to 200 yards 3" groups, I did not shoot further than that. I'm sure the 195s would be fine on deer, experiment with different powders and see what you get. I used 777 and have heard good things about BH209Looking at 195 grain duplex bullet in 50 caliber anyone have infor on this load or use it ?