Personally, I would go for the 280 AI. Why? Because hardly anyone else has one! I think the 280 is a very much overlooked caliber, capable of doing anything that a 270 or '06 can do. Plus I'm a 7mm fan. My go to deer rifle is a 7mm-08, a 30 year old Remington Model 7FS that rivals the Kimber for weight. I chose the 7mm-08 because back then it was new and different, plus the rifle wasn't available in 284 Winchester!
TO answer one question from above about ammo prices - 270 and 30-06 can be bought cheaper because they are much more popular than the 7mm-08. It doesn't make them any better ballistically, just cost less. Its all personal preference.....
TO answer one question from above about ammo prices - 270 and 30-06 can be bought cheaper because they are much more popular than the 7mm-08. It doesn't make them any better ballistically, just cost less. Its all personal preference.....