I have the S&W XVR 460. I say go for it. The ability to choose between 45LC 454Casul and 460 makes it very versatile. Short range training and fun shooting I use 45 LC to keep it enjoyable and then long range training I'll use 454 or 460.
LAX Ammo has 300gr 460 at 1800 fps for $1.31 per round.